Thromboangiitis Obliterans sebagai Gangguan Vaskular Inflamasi yang Berkaitan dengan Paparan Tembakau: Tinjauan Literatur
DOI:
https://doi.org/10.31004/joecy.v6i1.8982Keywords:
Buerger's Disease, Inflamasi Vaskular, Paparan Tembakau, Thromboangiitis Obliterans, Tinjauan LiteraturAbstract
Thromboangiitis obliterans (TAO) atau penyakit Buerger merupakan gangguan vaskular inflamasi langka terkait paparan tembakau yang menyebabkan oklusi segmental pembuluh ekstremitas, dengan prevalensi tinggi pada pria muda Asia dan risiko amputasi signifikan. Tujuan penelitian ini adalah menyajikan tinjauan literatur komprehensif tentang epidemiologi, patofisiologi, diagnosis, dan tata laksana TAO. Jenis penelitian kualitatif deskriptif dengan pendekatan literature review; populasi seluruh literatur global TAO pasca-2020 di Google Scholar, sampel 18 artikel purposive dari 2021-2025. Instrumen data sekunder dari PubMed dan PMC, dianalisis melalui konten analisis tematik (reduksi, penyajian, kesimpulan). Hasil menunjukkan patofisiologi trifasik memicu iskemia kronis, diagnosis via kriteria Shionoya dan angiografi, terapi definitif berhenti merokok. Kesimpulan merekomendasikan skrining dini dan pencegahan anti-rokok untuk kurangi beban kesehatan di Indonesia.
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