Thromboangiitis obliterans: Tinjauan Mendalam terhadap Gangguan Vaskukar Terkait Merokok
DOI:
https://doi.org/10.31004/joecy.v6i1.8895Keywords:
Tromboangiitis obliterans, penyakit Buerger, merokok.Abstract
Tromboangiitis obliterans (disebut juga penyakit Buerger) adalah gangguan inflamasi yang langka yang memengaruhi pembuluh darah pada ekstremitas tubuh. Kondisi ini sangat terkait dengan kebiasaan merokok dan melibatkan faktor genetik serta respon sistem kekebalan tubuh dalam proses perkembangannya. Penyakit ini melibatkan peradangan, pembentukan bekuan darah, dan respons imun yang tidak normal, yang mengakibatkan gangguan aliran darah. Diagnosis ditegakkan berdasarkan gejala klinis, riwayat medis, pemeriksaan fisik, dan tes penunjang. Terapi utamanya adalah dengan menghentikan rokok, yang dianggap sebagai tindakan pengobatan yang definitif dan efektif. Diperlukan penelitian lebih lanjut untuk memahami mekanisme dasar penyakit ini dan mengembangkan pendekatan pengobatan yang lebih efisien. Intervensi pada tahap awal sangat penting guna mencegah amputasi dan meningkatkan kualitas hidup pasien.
References
Arkkila, Perttu ET. Thromboangiitis Obliterans (Buerger’s Disease). Orphanet Journal of Rare Diseases. 2020 Apr;(1). Available from: https://doi.org/10.1186/1750-1172- 1-14.
Fazeli B, Ligi D, Keramat S, Maniscalco R, Sharebiani H, Mannello F. Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences. 2021 Sept;(11):1736. Available from: https://www.ncbi.nlm.nih.gov/pmc/a rticles/PMC8535045/
Olin JW. Thromboangiitis Obliterans: 110 Years Old and Little Progress Made. J Am Heart Assoc. 2018 Dec (23). Available from: [PMC free article] [PubMed]
Le Joncour A, Soudet S, Dupont A, et al. French Buerger's Network. Long-Term Outcome and Prognostic Factors of Complications in Thromboangiitis Obliterans (Buerger's Disease): A Multicenter Study of 224 Patients. J Am Heart Assoc. 2018 Dec ;(23). Available from: [PMC free article] [PubMed]
Cacione DG, do Carmo Novaes F, Moreno DH. Stem cell therapy for treatment of thromboangiitis obliterans (Buerger's disease). Cochrane Database Syst Rev. 2018 Oct :(10). Available from: [PMC free article] [PubMed]
Vijayakumar, A., Tiwari, R., & Prabhuswamy, V. K. Thromboangiitis obliterans (Buerger’s disease)-current practices. 2018 Jan. Available from: https://www-ncbi-nlm-nih gov.translate.goog/pmc/articles/PM C3786473/?_x_tr_sl=en&_x_tr
_tl=id&_x_tr_hl=id&_x_t r_pto=tc
Fazeli B, Seyed Abdolrahim Rezaee. A review on thromboangiitis obliterans pathophysiology: thrombosis and angiitis, which is to blame? Vascular. 2018 Jun;19(3):141–53. Available from: https://doi.org/10.1258/vasc.2010.ra 0045
Rafał Małecki, Kluz J, Przeździecka- Dołyk J, Adamiec R. The Pathogenesis and Diagnosis of Thromboangiitis obliterans: Is It Still a Mystery?. 2019 Jan ;24(6):1085-97. Available from: https://doi.org/10.17219/acem/3332 2
Apriliana S. Thromboangitis obliterans (TAO): Diagnosis Dan Tatalaksana. Cermin Dunia Kedokteran. 2021;48(12):713. Available from: doi:10.55175/cdk.v48i12.169
Zheng P, Wang W. Buerger’s disease: Autoimmune disease involving multiple hypersensitivity types. 2020; doi:10.21203/rs.3.rs- 86283/v1
Shapouri-Moghaddam, Abbas et al. “Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series.” Reports of biochemistry & molecular biology 2021; 9(4): 379-384.
Zierhut M and Smith J. Intraocular Inflammation : Thromboangiitis Obliterans. Springer-Verlag Berlin Heidelberg. 2019:775. Available from: DOI 10.1007/978-3-540- 75387-2_63
Qaja E, Muco E, Hashmi MF. Buerger Disease [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Oct 27]. Available https://www.ncbi.nlm.nih.gov/books /NBK430858/#_article-18685_s10_
Li ZF, Shu XJ, Wang WH, Liu SY, Dang L, Shi YQ, Bai YW. Predictive value of serum VEGF, IL-1 and TNF-α in the treatment of thromboangiitis obliterans by revascularization. Exp Ther Med. 2020 Dec ;20(6):232. Available from: doi: 10.3892/etm.2020.9362. Epub 2020 Oct 16. PMID: 33149786; PMCID: PMC7604734.
Bae M, Chung SW, Lee J, Kim E, Kang G, Jin M. Early Diagnosis and Intervention Are Needed for a Reasonable Prognosis of Thromboangiitis Obliterans. J Chest Surg. 2023 Sep 5;56(5):328-335. Available from: doi: 10.5090/jcs.22.148. Epub 2023 May 30. PMID: 37248718; PMCID: PMC10480401.
Piazza, G., & Creager, MA. Tromboangiitis obliterans. Circulation, 2020;121(16):1858- 1861.
Fazeli, B., Ravari, H., & Malekmakan, L. Buerger's disease: A comprehensive review. Journal of Research in Medical Sciences, 2018;21(2).
Olin, J. W. Thromboangiitis obliterans (Buerger's disease). New England Journal of Medicine, 2020;343(12):864-869.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Hyldathia Emily
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
