Aktivitas Tonikum Infusa Bunga Telang (Clitoria ternatea L.) terhadap Mencit dengan Metode Natatory Exhaustion dan Induksi Tidur
DOI:
https://doi.org/10.31004/joecy.v6i1.8214Keywords:
Butterfly Pea Flower, Infusion, Natatory Exhaustion, Sleep Induction, TonicAbstract
ABSTRACT
Tonics are agents that can stimulate body activity, thereby delaying feelings of fatigue, lethargy, and exhaustion. This study aimed to determine the ability of butterfly pea flower infusion to increase swimming time and its potential effect on the sleep duration of mice, as well as to evaluate the relationship between dose variation and tonic effects. Butterfly pea flower contains secondary metabolites such as alkaloids and flavonoids, which are known to produce tonic effects. This experimental study used 25 mice as test animals, divided into five groups. The test groups consisted of a negative control (distilled water), a positive control (caffeine 100 mg), and butterfly pea flower infusion at doses of 10%, 20%, and 40%. The results showed that butterfly pea flower infusion exhibited tonic effects in both the natatory exhaustion and sleep induction methods. The 10% dose produced tonic effects of 38.99% ± 10.34% in the natatory exhaustion method and 17.72% ± 6.13% in the sleep induction method. The 20% dose resulted in tonic effects of 52.82% ± 7.39% and 39.38% ± 6.22%, respectively. The 40% dose produced the greatest tonic effect, with values of 79.53% ± 3.82% in the natatory exhaustion method and 59.55% ± 1.72% in the sleep induction method.
Keywords: Butterfly Pea Flower, Infusion, Natatory Exhaustion, Sleep Induction, Tonic
References
Annisa, F.N., Fauziyyah, G.F., Wicaksono, I.A. & Lestari, A. 2022. Review Artikel: Potensi Tanaman Herbal Di Indonesia Dalam Meningkatkan Kebugaran Tubuh. Jurnal Ilmiah Farmasi Farmasyifa, 5(2): 161–182.
Depkes RI. 2017. Farmakope Herbal Indonesia. II ed. Jakarta: Departemen Kesehatan Republik Indonesia.
Dharmayanti, L., Novia, D. & Munawar, A. 2022. Uji Efek Tonikum Sediaan Sirup Bunga Telang (Clitoria ternatea L.) Terhadap Mencit Putih Jantan (Mus musculus). Jurnal Ilmiah Pharmacy, 9(2): 127–135.
Efendi, Y.N., Salimah, S. & Saputri, A.I. 2023. Optimasi Pelarut Etanol Air Dalam Proses Ekstraksi Terhadap Kadar Senyawa Steroid Ekstrak Daun Senduduk Bulu(Clidemia hirta (L .) D. Don). Health Sciences and Pharmacy Journal, 7(1): 1–5.
Fadila, V.N., Ardiyantoro, B. & Listyani, T.A. 2025. Uji Aktivitas Stimulansia Infusa Daun Cokelat (Theobroma cacao L.) Pada Mencit Putih (Mus musculus). Jurnal Ilmiah Farmasi Imelda, 9(1): 17–24.
Fikayuniar, L., Amallia, S., Azzahra, A.J., Anisa, M.A., Sagala, B.C. & Irawan, L. 2023. Skrinning Fitokimia Serta Uji Karakteristik Simplisia Dan Ekstrak Bunga Telang (Clitoria ternatea L.) Dengan Berbagai Metode. Jurnal Ilmiah Wahana Pendidikan, 9(15): 308–320.
Herdayanti, S., Lestari, I. & Sani, F. 2021. Efek Tonikum Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata schoot.) Pada Mencit Putih Jantan (Mus musculus). Indonesian Journal of Pharma Science, 1(1): 1–10.
Hesturini, R.J., Vadia, A.P. & Sari, F. 2022. Uji Aktivitas Tonikum Ekstrak Etanol Daun Seledri (Apium graveolens L.) Metode Natatory Exhaustion. Jurnal Farmasi Tinctura, 4(1): 1–6.
Hidayah, H., Nurhalimah, Nurhamidah, W. & Mindawati, E. 2024. Analisa kafein pada tumbuhan dengan metode HPLC. Jurnal Kesehatan Tambusai, 5(1): 130–137.
Imanda, Y.L., Yanti, S.P. & Sriwijaya, R.A. 2024. Uji Efek Tonikum Ekstrak Daun Teh Hijau (Camellia sinensis L.) Terhadap Mencit Putih Jantan Galur (Swiss webster) Dengan Metode Natatory Exhaustion Dan Rotarod Test. Jurnal Riset Kesehatan Modern, 6(2): 1–11.
Marjoni, R. 2021a. Analisis Farmakognosi Untuk Mahasiswa Farmasi. Jakarta: CV. Trans Info Media.
Noer, S.F., Wandira, A., Ashari, A.M., Apindati, R.K., Tavita, G.E. & Dilla, S. 2023. Tonicum Activity of Red Ginger (Zingiber officinale var . Rubrum) and Elephant Ginger (Zingiber officinale var . Roscoe) Ethanol Extract in Vivo. Jurnal Biologi Tropis, 23(2): 176–181.
Puspitasari, J., Wardani, T.S. & Listyani, T.A. 2024. Uji Efek Tonikum Ekstrak Etanol Jahe Emprit (Zingiber officinalle var) Terhadap Mencit (Mus musculus). Jurnal Kajian Ilmiah Multidisipliner, 8(10): 64–77.
Raihan & Dalimunthe, G.I. 2022. Uji Sitotoksisitas Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Dengan Metode Brine Shrimp Lethality Test (BSLT). Journal of Health and Medical Science, 1(3): 187–202.
Samson, E., Ridwan, W.A.H. & Baszary, C.D.U. 2019. Potensi Sedatif-Hipnotik Daun Kayu Galala (Erythrina Lithosperma) Sebagai Kandidat Obat Insomnia. Jurnal Matematika, Sains, dan Teknologi, 20(2): 83–94.
Sari, A.K., Fikri, M. & Febrianti, D.R. 2019. Pengukuran Rendemen Dan Identifikasi Senyawa Metabolit Sekunder Pada Ekstrak Daun terap (Artocarpus odoratissimus Blanco) Dengan Variasi Pelarut. Jurnal Insan Farmasi Indonesia, 2(2): 231–240.
Sari, E.K., Anantarini, N.P.D. & Dellima, B.R. 2024. Uji Aktivitas Antiinflamasi Ekstrak Etanol Daun Serai Wangi (Cymbopogon nardus L.) Secara In Vitro Dengan Metode HRBC (Human Red Blood Cell). KARTIKA: JURNAL ILMIAH FARMASI, 9(April): 1–17.
Serang, Y. & Silviana, S.D. 2019. Uji Efek Tonikum Ekstrak Buah Petai (Parkia speciosa hask.) Terhadap Mencit Jantan Galur Swiss Dengan Metode Natatory Exhaustion. Jurnal Farmasi & Sains Indonesia, 2(1): 71–74.
Sintia, D., Syarifah & Sunarti, R.N. 2023. Skrining Fitokimia Jamur Endofit Pada Buah Jambu Nasi-Nasi (Syzygium zeylanicum). Prosiding SEMNAS BIO, 531–539.
Suri, N., Widodo, S. & Yulianti, M.I. 2021. Uji Efek Stimulan Fraksi N-Heksan Daun Pegagan (Centella asiatica L.). Jurnal Farmasi Lampung, 10(2): 121–130.
Tari, M. & Indriyana, D. 2021. Uji Efek Tonikum Ekstrak Etanol Daun Kopasanda (Chromolaena odorata L.) Terhadap Mencit Putih Jantan Dengan Metode Natatory Exhaustion. Jurnal Ilmiah Bakti Farmasi, 6(1): 21–34.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Eli Yuliana. H, Siwi Hastuti , Rahmat Hidayat
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
