Formulasi Dan Uji Aktivitas Serum Anti Jerawat Ekstrak Daun Kelor (Moringa Oleifera L) Terhadap Propionibacterium Acnes
DOI:
https://doi.org/10.31004/joecy.v6i1.7941Keywords:
Moringa Oleifera, Anti-Acne Serum, Propionibacterium Acnes, Antibacterial Test, Formulation, Moringa Oleifera, Serum Anti Jerawat, Propionibacterium Acnes, Uji Antibakteri, FormulasiAbstract
Acne (acne vulgaris) is an inflammation of the pilosebaceous unit commonly caused by Propionibacterium acnes bacteria. One potential natural treatment alternative is Moringa oleifera L. leaves, which are known to contain active compounds such as flavonoids, tannins, saponins, alkaloids, and terpenoids with antibacterial activity. This study aims to design an anti-acne serum formulation from Moringa leaf extract and test its antibacterial activity against Propionibacterium acnes. The results of physical evaluation showed that all formulas met the requirements for serum preparations. The antibacterial activity test produced an average inhibition zone diameter of 3.58 mm (F1), 5.37 mm (F2), and 7.35 mm (F3). The positive control (erythromycin 2%) produced an inhibition zone of 33.1 mm. Statistical analysis (One Way ANOVA) showed a significant difference (p<0.05) between treatment groups, with the F8% formula providing the best antibacterial activity (moderate category). This study concluded that Moringa leaf extract can be formulated into a physically stable anti-acne serum. A formula with an extract concentration of 8% was optimal, with the strongest antibacterial activity against Propionibacterium acnes.
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